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2 opiate agonist drugs, methadone and also LAAM (levo-alpha-acetylmethadol), have been accepted for the therapy of opiate dependency. Agonists act by replacing at the opioid receptor website, therefore blocking the ecstasy of subsequently provided narcotics (through crosstolerance) and also inhibiting the symptoms of persistent and acute abstaining. Methadone was authorized for usage in 1972, as well as there are presently an estimated 650 methadone maintenance programs throughout the United States (IOM, 1995a, b). In 1993, LAAM was authorized for use in dealing with opiate dependancy; this medication has the benefit of requiring 3 dosages each week as opposed to day-to-day dosages, thus freeing subjects from day-to-day clinic participation.
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